•   专家顾问
  • 牛樟芝相关产业专家顾问-张春生 先生

牛樟芝相关产业专家顾问-张春生 先生

* 来源 : * 作者 : admin * 发表时间 : 2017-06-02 * 浏览 : 8

张春生 先生

【现职】

  • 南台科技大学 生物科技系暨研究所教授2012/03-

  • 南台科技大学 生技产品技研中心 主任 2004/08-

  • 南台科技大学 生物科技系暨研究所 主任 2013/08-

  • 台南市中小企业服务团 生技团长 2011/08-

  • 台湾生技产业联盟 理事长 2016/02

 

【学历】

  • 国立成功大学 化学工程学系  学士

  • 国立成功大学 化学工程研究所 硕士

  • 国立成功大学 化学工程研究所 博士

  

【经历】

  • 国立成功大学 化学系 助教1992 /81993/7

  • 长兴化学工业股份有限公司 电子材料部 研究员 1998 /72000/6

  • 南台科技大学 化学工程学系 助理教授 2000/82002/7

  • 南台科技大学 生物科技系暨研究所 助理教授 2002/8-2004/12

  • 南台科技大学 生物科技系暨研究所 副教授 2005/1-2012/02

  • 台湾生技产业联盟 秘书长 2013/04-2016/01


【专长】

  • 酵素工程

  • 发酵工程

  • 生化工程

  • 药物动力分割

 

【期刊论文】

  • Ng, I. S., Zheng, X., Chen, B. Y., Chi, X., Lu, Y. and Chang, C. S. 2013. Proteomics Approach to Decipher Novel Genes and Enzymes Characterization of a Bioelectricity-generating and Dye-decolorizing Bacterium Proteus hauseri ZMd44. Biotechnology and Bioprocess Engineering 18: 8-17

  • Chang,Ho, S. C., 2011. Enantioselective esterification of (R,S)-2-methylalkanoicacid with Carica papaya lipase in organic solvents. Biotechnol Lett, 33:2247–2253 [NSC- 96-2221-E-218 -029]

  • Chan, Y. Y., Chang, C. S., Chien, L. H. Wu, T. F. 2010. Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata are mediated via down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell. Journal of Ethnopharmacology, 127, 652-661 

  • Lu, H. E., Jian, C. H., Chen, S. F., Chen, T. M., Lee, S. T., Chang*, C. S., Weng*, C. F., 2010 Hypoglycemic effects of solid-state fermented mycelium of Paecilomyces farinosus (G30801) on high-fat fed with streptozotocin-induced diabetes rat. Indian Journal of Medical Research 131,696-701

  • Chang, C. S., Wu, P. L., 2009. Synthesis of triglycerides of phenylbutyric acids by lipase-catalyzed glycerolysis in a solvent-free system. Journal of Molecular Catalysis. B, Enzymatic, 61, 117-122 [NSC-93-2214-E-218-001]

  • Wu, T. F., Huang, W. C., Chen, Y. C., Tsay, Y. G., Chang, C. S.*, 2009. Proteomic investigation of the impact of oxygen on the protein profiles of hyaluronic acid-producing Streptococcus zooepidemicus. Proteomics, 9, 4507–4518

  • Chang, C. S. and Wu, P. L., 2007. Synthesis of triglycerides of phenylalkanoic acids by lipase-catalyzed esterification in a solvent-free system. 127, 694-702. (SCI 2007 IF=2.565) [NSC 92-2214-E-218 -002]

  • Chang, C. S., and Hsu, C. S., 2005. Enhancement of enantioselectivity and reaction rate on the synthesis of (S)-ketoprofen hydroxyalkyl ester in organic solvents via isopropanol-dried immobilized lipase. J. Chem. Technol. Biotechnol. 80, 537-544(SCI) [NSC-90-2214-E-218-003]

  • Chang, C. S., Su, C. C., Zhuang, J. R., and Tsai, S. W. 2004. Enhancement of enantioselectivity on the synthesis of (S)-naproxen morpholinoalkyl ester prodrugs in organic solvents using isopropanol-dried immobilized lipase. Journal of Molecular Catalysis. B, Enzymatic30:151-157

  • Chang, C. S., and Hsu, C. S., 2003. Lipase-catalyzed enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media. Biotechnol. lett. 25, 413-416. (SCI) [NSC-90-2214-E-218-003]

  • Chang, C. S., and Tsai, S. W., 1999. Lipase-catalyzed dynamic resolution of naproxen thioester by thiotransesterification in isooctane, Biochemical Engineering Journal, 3, 239-242. (SCI) [NSC 87-2214-E-006-006]

  • Chang, C. S., and Tsai, S. W. and Kuo, J., 1999. Lipase-catalyzed dynamic resolution of naproxen 2,2,2-trifluoroethyl thioester by hydrolysis in isooctane, Biotechnol. and Bioeng., 64(1), 120-126. (SCI) [NSC 87-2214-E-006-006]

  • Tsai, S. W., Lin, S. F., and Chang, C. S., 1999. Lipase-catalyzed enantioselective esterification of S(+)-naproxen ester prodrugs in cyclohexane, J. Chem. Technol. Biotechnol., 74, 751-758. (SCI) [NSC 84-2214-E-006-026]

  • Tsai, S. W., Tsai, C. S., and Chang, C. S., 1999. Lipase-catalyzed synthesis of (S)-Naproxen ester prodrug by transesterification in organic solvents, Applied Biochemistry and Biotechnology, 80, 205-219.

  • Chang, C. S., Tsai, S. W., and Lin, C. N. 1998. Enzymatic resolution of (R,S)-2-arylpropionic acid thioesters by Candida rugosa lipase-catalyzed thiotransesterification or hydrolysis in organic solvents, Tetrahedron: Asymmetry, 9, 2799-2807. (SCI) [NSC 87-2214-E-006-006]

  • Chang, C. S. and Tsai, S. W., 1998. Enantioselective adsorption of (+)-(S)-Naproxen in a cross-linked lipase in organic solvents, Separation Science and Technology. 33, 2113-2122. (SCI) [NSC 86-2214-E-006-004]

  • Huang, W. C., Tsai, S. W., and Chang, C. S., 1998. Enantioselective esterification of (S)-Naproxen from racemic Naproxen by alkylated lipase in organic solvents, J. Chin. Inst. Chem. Engrs., 29, 153-159.

  • Chang, C. S. and Tsai, S. W., 1997. A facile enzymatic process for the preparation of (S)-Naproxen ester prodrug in the organic solvents, Enzyme and Microb. Technol., 20, 635-639. (SCI) [NSC 84-2214-E-006-026]

  • Chang, C. S. and Tsai, S. W., 1997. Surfactant effect on enhancing (S)-Naproxen prodrug production from racemic Naproxen by lipase, Applied Biochemistry and Biotechnol. Part A: Enzyme Eng. and Biotechnol., 68, 135-142. (SCI) [NSC 84-2214-E-006-026]

  • Tsai, S. W., Liu, B. Y. and Chang, C. S., 1996. Enhancement of (S)-Naproxen ester productivity from racemic Naproxen by lipase in organic solvents, J. Chem. Technol. Biotechnol., 65, 156-162. (SCI) [NSC 82-0402-E-006-068]

  • Tsai, S. W., Lu, C. C. and Chang, C. S., 1996. Surfactant enhancement of (S)-Naproxen ester productivity from racemic Naproxen by lipase in isooctane, Biotechnol. and Bioeng., 51, 148-156. (SCI) [NSC 84-2214-E-006-026]

  • Tsai, S. W., Lin, C. C. and Chang, C. S., 1996. Enantioselective esterification of Naproxen in AOT/isooctane reversed micelles by lipase, ChIChE, 27, 201-204. [NSC 83-0402-E-006-025]

  • Tsai, S. W., Lu, C. C. and Chang, C. S., 1993. Kinetic of lipase-catalyzed hydrolysis of lipids in biphasic organic-aqueous systems, J. Chem. Technol. Biotechnol., 57, 147-154. (SCI)

  • Tsai S. W., Lin, J. J., Chang, C. S. and Chen, J. P., 1997. Enzymatic synthesis of (S)-ibuprofen ester prodrug from racemic ibuprofen by lipase in organic solvents, Biotechnol. Progress, 13, 82-86. (SCI) [NSC 84-2214-E-006-026]

  • 张春生, 1991, 基因工程开发新型生物战剂可行性研究, 化学兵学术季刊, 31, 39-43.

【研讨会论文】

  1. Chen-Chieh Lin, Yu-Yi Chan, Ching-Ping Chang, Song-Tay Lee, Ting-Feng Wu, Chien-Feng Li, Chu-Mao Yu, Lan-Hsiang Chien, Chun-Sheng Chang, 2015626-20156271Exploitation of the health-promoting properties of pomegranate juice through microbial fermentation, 2015生物技术暨生物工程国际研讨会

  2. Yi-Chao Tseng, Ming-Yang Chen, Chun-Sheng Chang and Jian-Chyi Chen, 2013130-201321日,The water extract of mycelium from solid-state fermentation of Phellinus igniarius induces cell cycle arrest on Carcinoma Cells, 21届细胞及分子生物新知研讨会

  3. 张巧宜、江芝谊、张春生, 20121220, 探讨不同发酵条件对固态培养Aspergillus属真菌对生产碱性蛋白酶之影响, 2012保健产品趋势研讨会暨海报竞赛

  4. Xiu-Min Zeng, Tsung-Ta Tu, Ming-Yang Chen, Chun-Sheng Chang and Jian-Chyi Chen, 201227-201229, The Bioactivity Study of Fermented Liquid or Solid State from Laetiporus sulphures, , 20 届细胞及分子生物新知研讨会

  5. 张春生,李松泰,翁庆丰,张菁萍,林茂村¸, 2010624-25日,虫草属真菌发酵产物之功能性开发,第16届生化工程研讨会,P13

  6. Hong-Sheng Wang, Ming-Yang Chen, Chun-Sheng Chang, Jian-Chyi Chen, 2010624-25日¸The Fermented liquid and water extract of mycelium from Phellinus igniarius cell-cycle arrest in breast carcinoma cell¸第16届生化工程研讨会,P364

  7. 朱懋育, 张春生,2010625-26日,用番木瓜脂肪酶在有机溶剂环境中进(R,S) -2-甲基己酸酯之水解动分割,第15届生化工程研讨会,P72

  8. 王淦戊,李松泰,张春生,2010625-26日,豆荚螟细胞无血清培养基组成之筛选,第15届生化工程研讨会,P213

  9. 王宏圣, , 陈建祺, 郑晖腾,.张春生,2010625-26日,探讨同碳源液态发酵桑黄对抑制癌细胞能之影响,第15届生化工程研讨会,P298

  10. Chun-Ling Lin, Chun-Sheng Chang, Jian-Chyi Chen, 2010120-22,The anti-tumor activities of different extracts of solid state fermented rice from Paecilomyces farinosus,  Eighteen Symposium on Recent Advances in Cellular and Molecular Biology

  11. 田仲源,张春生,200965-6日,固态培养Aspergillus属真菌生产酸性蛋白酶,第十四届生化工程研讨会,P130

  12. 林宥任,张春生,200965-6日,萃取金针菇废弃菇脚多醣之条件探讨,第十四届生化工程研讨会,P316

  13. 莫博钦, 张春生, 200965-6日,凝孢乳酸菌最适化培养条件探讨,第十四届生化工程研讨会,P156

  14. Chun-Sheng Chang*, Suu-Ching Ho, Shau-Wei Tsai 2008. Effect of alkyl chain length on the enantioselectivity of Carica papaya lipase in the kinetic resolution of 2-methylalkanoic acids, 14th Symposium of Young Asian Biochemical Engineers' Community, , Nov. 29-Dec. 1, p. 154, Shibaura Institute of Technology Toyosu Campus (Tokyo), Japan

  15. Chun-Sheng Chang*, Suu-Ching Ho, Shau-Wei Tsai 2008. Enantioselectivity esterification of (R,S)-2-methylalkanoic acid via Carica papaya lipase in organic solvents, 2008 Biocatalysis., July, 6-11, Bryant University, Rhode Island, USA

  16. 林钰寰,张春生,20086月,批式发酵条件对酪酸菌培养之影响,第十三届生化工程研讨会

  17. 蔡铠懋、张春生,20086月,液态发酵培养基组成对桑黄生产胞外多醣之影响,第十三届生化工程研讨会

  18. Jui Chin Li, Ching-Feng Weng, Chun-Sheng Chang and Jian Chyi Chen, , 2008, Jan. 23-25, The immunomodulatory and androgen secretion activity of extracts from different types Cordyceps sp. and cultures Cordyceps mycelia, 16th Symposium on recent advances in Cellular and Molecular Biology

  19. Ting-Feng Wu, Yeou-Guang Tasy, Yi-Chun Chen, Wei-Chih Huang, Tsae-Jen Tsai, Chun-Sheng Chang*, 2007, Dec. 4-5, Investigation of the impact of oxygen on the protein profiles of hyaluronan-producing bacteria Streptococcus zooepidemicus, Taiwan Proteomics Society International Conference 2007.

  20. 李松泰、林家俐、张春生,20077月,Paceilomyces farinosus菌丝体抽取物可减轻热卒中时脑血管功能异常,第六届海峡两岸心血管科学研讨会,p 87,新疆乌鲁木齐市,基础医学与临床,第27卷增刊,ISSN 1001-6325.

  21. 张春生、何思静,200711月,利用番木瓜脂解酵素在有机溶剂环境中镜像选择(R,S- 2 -甲基烷酸之酯化反应,2007台湾化学工程学会第54届年会暨国科会化工学门成果发表会

  22. 张春生、蔡采臻、陈健祺、孙明详,20076月,液态培养白殭菌生产胞外多醣最适培养条件之探讨,第十二届生化工程研讨会

  23. 张春生、 刘盈芬,20076月,批次高密度培养纳豆菌之发酵条件探讨,第十二届生化工程研讨会

  24. 张春生、高秀祯、吴宪政, 20076月,纳豆菌液态发酵对肠胃道病原菌及万古霉素抗药性肠球菌之抑菌能力探讨,第十二届生化工程研讨会(海报论文佳作)

  25. 张春生、汤凯宇、 陈启桢、陈健祺,20071月,液态发酵绣球菌之胞内与胞外多醣活化巨噬细胞 RAW 264.7 产生抗肿瘤效应之研究,中华民国真菌学会95年度年会暨会员大会

  26. Chun-Sheng Chang , Mei-Fen Luo, Application of factorial design to the study of parameters affecting the lipase-catalyzed dynamic kinetic resolution Naproxen 2,2,2-trifluoroethyl thioester by thiotransesterification in isooctane, 12th Symposium of Young Asian Biochemical Engineers' Community, 2006, Nov. 25-27, p. 138, I-Shou University, Kaohsiung County, Taiwan (ISBN-13:978-957-29172-3-7, ISBN-10:957-29172-3-4)

  27. Chun-Sheng Chang and Yu-Jen Chang, Anti-tumor activity of the fermented broth of Paceilomyces farinosus, 12th Symposium of Young Asian Biochemical Engineers' Community, 2006, Nov. 25-27, p. 83, I-Shou University, Kaohsiung County, Taiwan(ISBN-13:978-957-29172-3-7, ISBN-10:957-29172-3-4)

  28. 张于仁、张春生,20066月,虫草属真菌之生物活性物质对癌细胞之影响,第十一届生化工程研讨会(海报论文佳作)

  29. 张春生、吴沛玲,20066月,利用脂解酵素催化醇解反应进行三苯基丁酸甘油酯前驱药合成,第十一届生化工程研讨会

  30. 张春生、邱继正,20056月,影响纳豆激酶生产之液态发酵条件探讨,第十届生化工程研讨会

  31. 曾诗雯、张春生, 20046, 利用脂解酵素催化动力分割合成(S)-Naproxen Piperazinylalkyl ester 前驱药, 第九届生化工程研讨会暨农业生物产业研讨会, 96.

  32. 庄嘉荣、张春生, 20046,有机溶剂中以脂解酵素催化转酯化动态动力分割制备(S)-Naproxen morpholinoalkyl酯类前驱药, 第九届生化工程研讨会暨农业生物产业研讨会, 95.

  33. 张春生、刘昆辅, 20046, 有机溶剂中利用脂解酵素催化动态动力分割制备(S-Naproxen hydroxyalkyl ester 前驱药, 第九届生化工程研讨会暨农业生物产业研讨会, 98.

  34. Chun-Sheng Chang, Chien-Chig Su, Improvement of enantioselectivity on the synthesis of (S)-ketprofen hydroxyalkyl ester in organic solvents via isopropanol-dried immobilized lipase, The 10th Symposium of Young Asian Biochemical Engineers' Community, 2004, Sep. 23-25 p.120, Osaka, Japan.

  35. 吴沛玲、张春生,200411月,利用脂解酵素进行三芳香族脂肪酸甘油酯前驱药合成,中国化工年会暨国科会成果发表会

  36. 张春生, 20045, 生物触媒-酵素在现代工业所扮演的角色, 陆军官校八十周年校庆综合学术研讨会暨国科会国防科技航空科技学门研究成果发表会化学组, 17-20.

  37. 张春生, 庄嘉荣, 曾诗雯, 刘昆辅, 200311, 利用脂解酵素催化分割程序制备具光学活性之非类固醇消炎前驱药(II), 中国化工年会暨国科会成果发表会

  38. Chun-Sheng Chang, Chin-Shuo Hsu, 2003, Enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media: marked enhancement of enantioselectivity of immobilized lipase by isopropanol-dried treatment, The 9th Symposium of Young Asian Biochemical Engineers' Community, Nov. 13-15. Jeju Island, Korea.

  39. 徐景硕,张春生, 20036, 利用脂解酵素催化动力分割制备具镜像活性之 ketoprofen hydroxyalkyl ester酯类前驱药,第八届生化工程研讨会, 152.

  40. 苏健志,张春生, 20036, 有机溶剂中利用脂解酵素合成(S)-morpholinoalkyl naproxen esters 酯类前驱药,第八届生化工程研讨会, 151.

  41. 张春生,  200211月,利用脂解酵素催化分割程序制备具光学活性之非类固醇消炎前驱药, 中国化工年会暨国科会成果发表会

  42. 苏健志,张春生, 20026, 固定化脂肪脢在聚合胶体应用于(R,S)-Naproxen之动力分割,第七届生化工程研讨会, 339-343.

  43. 张春生, 蔡少伟, 2002, 自消旋Naproxen硫酯进行转酯化合成(S)-Naproxen前驱药,第十七届全国技术及职业教育研讨会, 工业类化工组论文集, 1605-1615.

  44. 张春生, 蔡少伟, 20014, 有机溶剂中制备(S)-Naproxen酯类前驱药的简便酵素制程, 第十六届全国技术及职业教育研讨会, 工业类化工组论文集, 351-360.

  45. Tsai, S. W. and Chang, C. S. 1998. Dynamic kinetic resolution of naproxen thioester by lipase in organic solvents, 10th International Symposium on Chiral Discrimination, Vienna, Austria.

  46. Chang, C. S. and Tsai, S. W. 1998. Dynamic resolution of naproxen thioester by hydrolysis and thiotransesterification by lipase in isooctane 4th YABEC, Nov, Hualien, ROC.

  47. Tsai, S. W., Tsai, C. S., and Chang, C. S., 1997. Synthesis of (S)-Naproxen ester prodrug by transesterification in organic solvents with lipase as biocatalyst, 3rd International Symposium on Biocastalysis and Biotransformation, September, La Grande Motte, France.

  48.  Tsai, S. W., and Chang, C. S., 1997. Chiral adsorption of (S)-Naproxen in cross-linked lipase, 9th International Symposium on Chiral Discrimination, October, Nagoya, Japan.

  49. Tsai, S. W. and, Chang, C. S. 1996. A facile enzymatic process for the preparation of (S)-Naproxen ester prodrug in the organic solvents., 8th International Symposium on Chiral Discrimination, June, Edinburgh, UK.

  50. Tsai, S. W., Liu, B. Y. and Chang, C. S., 1996. Enhancement of (S)-Naproxen ester productivity from racemic Naproxen by lipase in organic solvents, 7th APCChE Conference & Taipei Chem Exhibition. March, Taipei, R.O.C.

  51.  Tsai, S. W., Lu, C. C. and Chang, C. S., 1996. Surfactant enhancement of (S)-Naproxen ester productivity from racemic Naproxen by lipase in isooctane, 10th International Biotechnology Symposium and 9th International Symposium of Yeasts, August, Sydney, Australia.

 

【专利】

  • Shau- Wei Tsai; Chun-Sheng ChangProcess for preparing optically active (S)-α-aryl propionic acid or ester thereof

  • 蔡少伟,张春生,光学活性S形α-芳香取代基丙酸(profen)或其S形酯类之制造方法

  • 张春生,三苯基脂肪酸甘油脂的酵素合成方法

  • 张春生、李松泰、翁庆丰,使用经由粉拟青霉菌(Paecilomyces farinosus) G30801的培育而得到的产物来治疗第1型或第2型糖尿病

  • 李松泰、张春生、张菁萍、林茂村,利用一由粉拟青霉菌(Paecilomyces farinosus)G30801的培育而得到的产物来治疗热中风