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  • 牛樟芝相關產業專家顧問-張春生 先生

牛樟芝相關產業專家顧問-張春生 先生

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張春生 先生

【現職】

  • 南台科技大學 生物科技系暨研究所教授2012/03-

  • 南台科技大學 生技產品技研中心 主任 2004/08-

  • 南台科技大學 生物科技系暨研究所 主任 2013/08-

  • 台南市中小企業服務團 生技團長 2011/08-

  • 臺灣生技產業聯盟 理事長 2016/02

 

【學歷】

  • 國立成功大學 化學工程學系  學士

  • 國立成功大學 化學工程研究所 碩士

  • 國立成功大學 化學工程研究所 博士

 

【經歷】

  • 國立成功大學 化學系 助教1992 /81993/7

  • 長興化學工業股份有限公司 電子材料部 研究員 1998 /72000/6

  • 南台科技大學 化學工程學系 助理教授 2000/82002/7

  • 南台科技大學 生物科技系暨研究所 助理教授 2002/8-2004/12

  • 南台科技大學 生物科技系暨研究所 副教授 2005/1-2012/02

  • 臺灣生技產業聯盟 秘書長 2013/04-2016/01

 

【專長】

  • 酵素工程

  • 發酵工程

  • 生化工程

  • 藥物動力分割

 

【期刊論文】

  1. Ng, I. S., Zheng, X., Chen, B. Y., Chi, X., Lu, Y. and Chang, C. S. 2013. Proteomics Approach to Decipher Novel Genes and Enzymes Characterization of a Bioelectricity-generating and Dye-decolorizing Bacterium Proteus hauseri ZMd44. Biotechnology and Bioprocess Engineering 18: 8-17

  2. Chang,Ho, S. C., 2011. Enantioselective esterification of (R,S)-2-methylalkanoicacid with Carica papaya lipase in organic solvents. Biotechnol Lett, 33:2247–2253 [NSC- 96-2221-E-218 -029]

  3. Chan, Y. Y., Chang, C. S., Chien, L. H. Wu, T. F. 2010. Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata are mediated via down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell. Journal of Ethnopharmacology, 127, 652-661 

  4. Lu, H. E., Jian, C. H., Chen, S. F., Chen, T. M., Lee, S. T., Chang*, C. S., Weng*, C. F., 2010 Hypoglycemic effects of solid-state fermented mycelium of Paecilomyces farinosus (G30801) on high-fat fed with streptozotocin-induced diabetes rat. Indian Journal of Medical Research 131,696-701

  5. Chang, C. S., Wu, P. L., 2009. Synthesis of triglycerides of phenylbutyric acids by lipase-catalyzed glycerolysis in a solvent-free system. Journal of Molecular Catalysis. B, Enzymatic, 61, 117-122 [NSC-93-2214-E-218-001]

  6. Wu, T. F., Huang, W. C., Chen, Y. C., Tsay, Y. G., Chang, C. S.*, 2009. Proteomic investigation of the impact of oxygen on the protein profiles of hyaluronic acid-producing Streptococcus zooepidemicus. Proteomics, 9, 4507–4518

  7. Chang, C. S. and Wu, P. L., 2007. Synthesis of triglycerides of phenylalkanoic acids by lipase-catalyzed esterification in a solvent-free system. 127, 694-702. (SCI 2007 IF=2.565) [NSC 92-2214-E-218 -002]

  8. Chang, C. S., and Hsu, C. S., 2005. Enhancement of enantioselectivity and reaction rate on the synthesis of (S)-ketoprofen hydroxyalkyl ester in organic solvents via isopropanol-dried immobilized lipase. J. Chem. Technol. Biotechnol. 80, 537-544(SCI) [NSC-90-2214-E-218-003]

  9. Chang, C. S., Su, C. C., Zhuang, J. R., and Tsai, S. W. 2004. Enhancement of enantioselectivity on the synthesis of (S)-naproxen morpholinoalkyl ester prodrugs in organic solvents using isopropanol-dried immobilized lipase. Journal of Molecular Catalysis. B, Enzymatic30:151-157

  10. Chang, C. S., and Hsu, C. S., 2003. Lipase-catalyzed enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media. Biotechnol. lett. 25, 413-416. (SCI) [NSC-90-2214-E-218-003]

  11. Chang, C. S., and Tsai, S. W., 1999. Lipase-catalyzed dynamic resolution of naproxen thioester by thiotransesterification in isooctane, Biochemical Engineering Journal, 3, 239-242. (SCI) [NSC 87-2214-E-006-006]

  12. Chang, C. S., and Tsai, S. W. and Kuo, J., 1999. Lipase-catalyzed dynamic resolution of naproxen 2,2,2-trifluoroethyl thioester by hydrolysis in isooctane, Biotechnol. and Bioeng., 64(1), 120-126. (SCI) [NSC 87-2214-E-006-006]

  13. Tsai, S. W., Lin, S. F., and Chang, C. S., 1999. Lipase-catalyzed enantioselective esterification of S(+)-naproxen ester prodrugs in cyclohexane, J. Chem. Technol. Biotechnol., 74, 751-758. (SCI) [NSC 84-2214-E-006-026]

  14. Tsai, S. W., Tsai, C. S., and Chang, C. S., 1999. Lipase-catalyzed synthesis of (S)-Naproxen ester prodrug by transesterification in organic solvents, Applied Biochemistry and Biotechnology, 80, 205-219.

  15. Chang, C. S., Tsai, S. W., and Lin, C. N. 1998. Enzymatic resolution of (R,S)-2-arylpropionic acid thioesters by Candida rugosa lipase-catalyzed thiotransesterification or hydrolysis in organic solvents, Tetrahedron: Asymmetry, 9, 2799-2807. (SCI) [NSC 87-2214-E-006-006]

  16. Chang, C. S. and Tsai, S. W., 1998. Enantioselective adsorption of (+)-(S)-Naproxen in a cross-linked lipase in organic solvents, Separation Science and Technology. 33, 2113-2122. (SCI) [NSC 86-2214-E-006-004]

  17. Huang, W. C., Tsai, S. W., and Chang, C. S., 1998. Enantioselective esterification of (S)-Naproxen from racemic Naproxen by alkylated lipase in organic solvents, J. Chin. Inst. Chem. Engrs., 29, 153-159.

  18. Chang, C. S. and Tsai, S. W., 1997. A facile enzymatic process for the preparation of (S)-Naproxen ester prodrug in the organic solvents, Enzyme and Microb. Technol., 20, 635-639. (SCI) [NSC 84-2214-E-006-026]

  19. Chang, C. S. and Tsai, S. W., 1997. Surfactant effect on enhancing (S)-Naproxen prodrug production from racemic Naproxen by lipase, Applied Biochemistry and Biotechnol. Part A: Enzyme Eng. and Biotechnol., 68, 135-142. (SCI) [NSC 84-2214-E-006-026]

  20. Tsai, S. W., Liu, B. Y. and Chang, C. S., 1996. Enhancement of (S)-Naproxen ester productivity from racemic Naproxen by lipase in organic solvents, J. Chem. Technol. Biotechnol., 65, 156-162. (SCI) [NSC 82-0402-E-006-068]

  21. Tsai, S. W., Lu, C. C. and Chang, C. S., 1996. Surfactant enhancement of (S)-Naproxen ester productivity from racemic Naproxen by lipase in isooctane, Biotechnol. and Bioeng., 51, 148-156. (SCI) [NSC 84-2214-E-006-026]

  22. Tsai, S. W., Lin, C. C. and Chang, C. S., 1996. Enantioselective esterification of Naproxen in AOT/isooctane reversed micelles by lipase, ChIChE, 27, 201-204. [NSC 83-0402-E-006-025]

  23. Tsai, S. W., Lu, C. C. and Chang, C. S., 1993. Kinetic of lipase-catalyzed hydrolysis of lipids in biphasic organic-aqueous systems, J. Chem. Technol. Biotechnol., 57, 147-154. (SCI)

  24. Tsai S. W., Lin, J. J., Chang, C. S. and Chen, J. P., 1997. Enzymatic synthesis of (S)-ibuprofen ester prodrug from racemic ibuprofen by lipase in organic solvents, Biotechnol. Progress, 13, 82-86. (SCI) [NSC 84-2214-E-006-026]

  25. 張春生, 1991, 基因工程開發新型生物戰劑可行性研究, 化學兵學術季刊, 31, 39-43.

  26.  

  27. 【研討會論文】

  28. Chen-Chieh Lin, Yu-Yi Chan, Ching-Ping Chang, Song-Tay Lee, Ting-Feng Wu, Chien-Feng Li, Chu-Mao Yu, Lan-Hsiang Chien, Chun-Sheng Chang, 2015626-20156271Exploitation of the health-promoting properties of pomegranate juice through microbial fermentation, 2015生物技術暨生物工程國際研討會

  29. Yi-Chao Tseng, Ming-Yang Chen, Chun-Sheng Chang and Jian-Chyi Chen, 2013130-201321日,The water extract of mycelium from solid-state fermentation of Phellinus igniarius induces cell cycle arrest on Carcinoma Cells, 21屆細胞及分子生物新知研討會

  30. 張巧宜、江芝誼、張春生, 20121220, 探討不同發酵條件對固態培養Aspergillus屬真菌對生產鹼性蛋白酶之影響, 2012保健產品趨勢研討會暨海報競賽

  31. Xiu-Min Zeng, Tsung-Ta Tu, Ming-Yang Chen, Chun-Sheng Chang and Jian-Chyi Chen, 201227-201229, The Bioactivity Study of Fermented Liquid or Solid State from Laetiporus sulphures, , 20 屆細胞及分子生物新知研討會

  32. 張春生,李松泰,翁慶豐,張菁萍,林茂村¸, 2010624-25日,蟲草屬真菌發酵產物之功能性開發,第16屆生化工程研討會,P13

  33. Hong-Sheng Wang, Ming-Yang Chen, Chun-Sheng Chang, Jian-Chyi Chen, 2010624-25日¸The Fermented liquid and water extract of mycelium from Phellinus igniarius cell-cycle arrest in breast carcinoma cell¸第16屆生化工程研討會,P364

  34. 朱懋育, 張春生,2010625-26日,用番木瓜脂肪酶在有機溶劑環境中進(R,S) -2-甲基己酸酯之水解動分割,第15屆生化工程研討會,P72

  35. 王淦戊,李松泰,張春生,2010625-26日,豆莢螟細胞無血清培養基組成之篩選,第15屆生化工程研討會,P213

  36. 王宏聖, , 陳建祺, 鄭暉騰,.張春生,2010625-26日,探討同碳源液態發酵桑黃對抑制癌細胞能之影響,第15屆生化工程研討會,P298

  37. Chun-Ling Lin, Chun-Sheng Chang, Jian-Chyi Chen, 2010120-22,The anti-tumor activities of different extracts of solid state fermented rice from Paecilomyces farinosus,  Eighteen Symposium on Recent Advances in Cellular and Molecular Biology

  38. 田仲源,張春生,200965-6日,固態培養Aspergillus屬真菌生產酸性蛋白酶,第十四屆生化工程研討會,P130

  39. 林宥任,張春生,200965-6日,萃取金針菇廢棄菇腳多醣之條件探討,第十四屆生化工程研討會,P316

  40. 莫博欽, 張春生, 200965-6日,凝孢乳酸菌最適化培養條件探討,第十四屆生化工程研討會,P156

  41. Chun-Sheng Chang*, Suu-Ching Ho, Shau-Wei Tsai 2008. Effect of alkyl chain length on the enantioselectivity of Carica papaya lipase in the kinetic resolution of 2-methylalkanoic acids, 14th Symposium of Young Asian Biochemical Engineers' Community, , Nov. 29-Dec. 1, p. 154, Shibaura Institute of Technology Toyosu Campus (Tokyo), Japan

  42. Chun-Sheng Chang*, Suu-Ching Ho, Shau-Wei Tsai 2008. Enantioselectivity esterification of (R,S)-2-methylalkanoic acid via Carica papaya lipase in organic solvents, 2008 Biocatalysis., July, 6-11, Bryant University, Rhode Island, USA

  43. 林鈺寰,張春生,20086月,批式發酵條件對酪酸菌培養之影響,第十三屆生化工程研討會

  44. 蔡鎧懋、張春生,20086月,液態發酵培養基組成對桑黃生產胞外多醣之影響,第十三屆生化工程研討會

  45. Jui Chin Li, Ching-Feng Weng, Chun-Sheng Chang and Jian Chyi Chen, , 2008, Jan. 23-25, The immunomodulatory and androgen secretion activity of extracts from different types Cordyceps sp. and cultures Cordyceps mycelia, 16th Symposium on recent advances in Cellular and Molecular Biology

  46. Ting-Feng Wu, Yeou-Guang Tasy, Yi-Chun Chen, Wei-Chih Huang, Tsae-Jen Tsai, Chun-Sheng Chang*, 2007, Dec. 4-5, Investigation of the impact of oxygen on the protein profiles of hyaluronan-producing bacteria Streptococcus zooepidemicus, Taiwan Proteomics Society International Conference 2007.

  47. 李松泰、林家俐、張春生,20077月,Paceilomyces farinosus菌絲體抽取物可減輕熱卒中時腦血管功能異常,第六屆海峽兩岸心血管科學研討會,p 87,新疆烏魯木齊市,基礎醫學與臨床,第27卷增刊,ISSN 1001-6325.

  48. 張春生、何思靜,200711月,利用番木瓜脂解酵素在有機溶劑環境中鏡像選擇(R,S- 2 -甲基烷酸之酯化反應,2007臺灣化學工程學會第54屆年會暨國科會化工學門成果發表會

  49. 張春生、蔡采臻、陳健祺、孫明詳,20076月,液態培養白殭菌生產胞外多醣最適培養條件之探討,第十二屆生化工程研討會

  50. 張春生、 劉盈芬,20076月,批次高密度培養納豆菌之發酵條件探討,第十二屆生化工程研討會

  51. 張春生、高秀禎、吳憲政, 20076月,納豆菌液態發酵對腸胃道病原菌及萬古黴素抗藥性腸球菌之抑菌能力探討,第十二屆生化工程研討會(海報論文佳作)

  52. 張春生、湯凱宇、 陳啟楨、陳健祺,20071月,液態發酵繡球菌之胞內與胞外多醣活化巨噬細胞 RAW 264.7 產生抗腫瘤效應之研究,中華民國真菌學會95年度年會暨會員大會

  53. Chun-Sheng Chang , Mei-Fen Luo, Application of factorial design to the study of parameters affecting the lipase-catalyzed dynamic kinetic resolution Naproxen 2,2,2-trifluoroethyl thioester by thiotransesterification in isooctane, 12th Symposium of Young Asian Biochemical Engineers' Community, 2006, Nov. 25-27, p. 138, I-Shou University, Kaohsiung County, Taiwan (ISBN-13:978-957-29172-3-7, ISBN-10:957-29172-3-4)

  54. Chun-Sheng Chang and Yu-Jen Chang, Anti-tumor activity of the fermented broth of Paceilomyces farinosus, 12th Symposium of Young Asian Biochemical Engineers' Community, 2006, Nov. 25-27, p. 83, I-Shou University, Kaohsiung County, Taiwan(ISBN-13:978-957-29172-3-7, ISBN-10:957-29172-3-4)

  55. 張于仁、張春生,20066月,蟲草屬真菌之生物活性物質對癌細胞之影響,第十一屆生化工程研討會(海報論文佳作)

  56. 張春生、吳沛玲,20066月,利用脂解酵素催化醇解反應進行三苯基丁酸甘油酯前驅藥合成,第十一屆生化工程研討會

  57. 張春生、邱繼正,20056月,影響納豆激酶生產之液態發酵條件探討,第十屆生化工程研討會

  58. 曾詩雯、張春生, 20046, 利用脂解酵素催化動力分割合成(S)-Naproxen Piperazinylalkyl ester 前驅藥, 第九屆生化工程研討會暨農業生物產業研討會, 96.

  59. 莊嘉榮、張春生, 20046,有機溶劑中以脂解酵素催化轉酯化動態動力分割製備(S)-Naproxen morpholinoalkyl酯類前驅藥, 第九屆生化工程研討會暨農業生物產業研討會, 95.

  60. 張春生、劉昆輔, 20046, 有機溶劑中利用脂解酵素催化動態動力分割製備(S-Naproxen hydroxyalkyl ester 前驅藥, 第九屆生化工程研討會暨農業生物產業研討會, 98.

  61. Chun-Sheng Chang, Chien-Chig Su, Improvement of enantioselectivity on the synthesis of (S)-ketprofen hydroxyalkyl ester in organic solvents via isopropanol-dried immobilized lipase, The 10th Symposium of Young Asian Biochemical Engineers' Community, 2004, Sep. 23-25 p.120, Osaka, Japan.

  62. 吳沛玲、張春生,200411月,利用脂解酵素進行三芳香族脂肪酸甘油酯前驅藥合成,中國化工年會暨國科會成果發表會

  63. 張春生, 20045, 生物觸媒-酵素在現代工業所扮演的角色, 陸軍官校八十周年校慶綜合學術研討會暨國科會國防科技航空科技學門研究成果發表會化學組, 17-20.

  64. 張春生, 莊嘉榮, 曾詩雯, 劉昆輔, 200311, 利用脂解酵素催化分割程式製備具光學活性之非類固醇消炎前驅藥(II), 中國化工年會暨國科會成果發表會

  65. Chun-Sheng Chang, Chin-Shuo Hsu, 2003, Enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media: marked enhancement of enantioselectivity of immobilized lipase by isopropanol-dried treatment, The 9th Symposium of Young Asian Biochemical Engineers' Community, Nov. 13-15. Jeju Island, Korea.

  66. 徐景碩,張春生, 20036, 利用脂解酵素催化動力分割製備具鏡像活性之 ketoprofen hydroxyalkyl ester酯類前驅藥,第八屆生化工程研討會, 152.

  67. 蘇健志,張春生, 20036, 有機溶劑中利用脂解酵素合成(S)-morpholinoalkyl naproxen esters 酯類前驅藥,第八屆生化工程研討會, 151.

  68. 張春生,  200211月,利用脂解酵素催化分割程式製備具光學活性之非類固醇消炎前驅藥, 中國化工年會暨國科會成果發表會

  69. 蘇健志,張春生, 20026, 固定化脂肪脢在聚合膠體應用於(R,S)-Naproxen之動力分割,第七屆生化工程研討會, 339-343.

  70. 張春生, 蔡少偉, 2002, 自消旋Naproxen硫酯進行轉酯化合成(S)-Naproxen前驅藥,第十七屆全國技術及職業教育研討會, 工業類化工組論文集, 1605-1615.

  71. 張春生, 蔡少偉, 20014, 有機溶劑中製備(S)-Naproxen酯類前驅藥的簡便酵素制程, 第十六屆全國技術及職業教育研討會, 工業類化工組論文集, 351-360.

  72. Tsai, S. W. and Chang, C. S. 1998. Dynamic kinetic resolution of naproxen thioester by lipase in organic solvents, 10th International Symposium on Chiral Discrimination, Vienna, Austria.

  73. Chang, C. S. and Tsai, S. W. 1998. Dynamic resolution of naproxen thioester by hydrolysis and thiotransesterification by lipase in isooctane 4th YABEC, Nov, Hualien, ROC.

  74. Tsai, S. W., Tsai, C. S., and Chang, C. S., 1997. Synthesis of (S)-Naproxen ester prodrug by transesterification in organic solvents with lipase as biocatalyst, 3rd International Symposium on Biocastalysis and Biotransformation, September, La Grande Motte, France.

  75. Tsai, S. W., and Chang, C. S., 1997. Chiral adsorption of (S)-Naproxen in cross-linked lipase, 9th International Symposium on Chiral Discrimination, October, Nagoya, Japan.

  76. Tsai, S. W. and, Chang, C. S. 1996. A facile enzymatic process for the preparation of (S)-Naproxen ester prodrug in the organic solvents., 8th International Symposium on Chiral Discrimination, June, Edinburgh, UK.

  77. Tsai, S. W., Liu, B. Y. and Chang, C. S., 1996. Enhancement of (S)-Naproxen ester productivity from racemic Naproxen by lipase in organic solvents, 7th APCChE Conference & Taipei Chem Exhibition. March, Taipei, R.O.C.

  78. Tsai, S. W., Lu, C. C. and Chang, C. S., 1996. Surfactant enhancement of (S)-Naproxen ester productivity from racemic Naproxen by lipase in isooctane, 10th International Biotechnology Symposium and 9th International Symposium of Yeasts, August, Sydney, Australia.

 

【專利】

  • Shau- Wei Tsai; Chun-Sheng ChangProcess for preparing optically active (S)-α-aryl propionic acid or ester thereof

  • 蔡少偉,張春生,光學活性S形α-芳香取代基丙酸(profen)或其S形酯類之製造方法

  • 張春生,三苯基脂肪酸甘油脂的酵素合成方法

  • 張春生、李松泰、翁慶豐,使用經由粉擬青黴菌(Paecilomyces farinosus) G30801的培育而得到的產物來治療第1型或第2型糖尿病

  • 李松泰、張春生、張菁萍、林茂村,利用一由粉擬青黴菌(Paecilomyces farinosus)G30801的培育而得到的產物來治療熱中風